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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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A Case of Ivermectin-Induced Warfarin Toxicity: First Published Report
Brian Wesley Gilbert1, Joe Slechta1
1Wesley Medical Center, Wichita, KS, USA.
Hospital Pharmacy
|December 19, 2018
Summary
This case report details a patient experiencing a sublingual hematoma while on warfarin and ivermectin. It highlights ivermectin
Area of Science:
- Pharmacology
- Hematology
- Clinical Medicine
Background:
- Warfarin is a common anticoagulant affecting vitamin K-dependent clotting factors.
- Ivermectin is an antiparasitic drug with potential interactions with coagulation.
- Limited human data exists on ivermectin's effect on the human coagulation system.
Purpose of the Study:
- To report the first human case of a sublingual hematoma associated with concomitant warfarin and ivermectin use.
- To investigate the potential interaction between warfarin and ivermectin in a clinical setting.
Main Methods:
- Case presentation of a patient with a large sublingual hematoma.
- Review of the patient's medication history, including warfarin and ivermectin.
- Analysis of the potential pharmacological interaction based on existing literature.
Main Results:
- A patient developed a significant hematoma under the tongue.
- The hematoma occurred during concurrent therapy with warfarin and ivermectin.
- Ivermectin's known in vitro interference with vitamin K-dependent clotting factors (II, V, VII, X) is noted.
Conclusions:
- Concomitant use of warfarin and ivermectin may increase the risk of bleeding events.
- This case suggests a potential for ivermectin to potentiate the anticoagulant effect of warfarin in humans.
- Further research is warranted to elucidate the clinical significance of this drug interaction.
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