Related Experiment Video
Updated: Jan 31, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
How Complex Can Resistance to Dieldrin, the Insect γ-Aminobutyric Acid Receptor, Get?
1Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
Abstract:
Recently, Taylor-Wells et al published evidence that the γ-aminobutyric acid (GABA) receptor, resistance to dieldrin (RDL), from mosquitoes undergoes RNA A-to-I editing to generate an extraordinarily large range of isoforms. This editing was found to affect GABA receptor pharmacology, as it influenced the potency of GABA and ivermectin. This highlights RNA editing as a species-specific mechanism to fine-tune receptor function as well as possibly increase tolerance of mosquitoes to certain insecticides. This commentary also considers novel findings from analysis of Rdl transcripts from individual mosquitoes taken from different geographical areas.
Related Concept Videos
Osmoregulation in Insects
Internal Receptors
Receptor-mediated Endocytosis
Resistivity
Resistance
Formation of Complex Ions

