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Related Experiment Video

Updated: Jan 31, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice.

Remco T Molenhuis1, Hilgo Bruining2, Myrna J V Brandt1

  • 11Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

Molecular Autism
|December 19, 2018
PubMed
Summary

The Collaborative Cross mouse model reveals that digging and activity behaviors are better for studying neurodevelopmental disorders than social recognition. This approach enhances understanding of genetic influences across diverse backgrounds.

Keywords:
Animal modelsAutismBehavioral neuroscienceGenetic reference populationHistamine 3 receptorNeurodevelopmental disordersQuantitative geneticsRepetitive behavior

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Area of Science:

  • Genetics
  • Neuroscience
  • Animal Models

Background:

  • Neurodevelopmental disorders (NDD) animal models often use single genetic mutations, contrasting with human genetics where Autism Spectrum Disorder (ASD) involves multiple genetic factors.
  • Translational research in NDD requires animal models that can quantitatively assess genetic insults across varied genetic backgrounds.

Purpose of the Study:

  • To investigate the quantitative genetic architecture of NDD-related behavioral phenotypes using a novel mouse genetic reference population.
  • To identify suitable behavioral phenotypes for quantitative studies in NDD animal models.

Main Methods:

  • Utilized the Collaborative Cross (CC), a genetically diverse mouse population.
  • Assessed various behavioral phenotypes, including social recognition, grooming, digging, locomotor activity, and stereotyped exploratory patterns.

Main Results:

  • Social recognition and grooming phenotypes showed limited heritability and were insufficient for quantitative NDD studies.
  • Digging, locomotor activity, and stereotyped exploration exhibited continuous distributions and mapped to quantitative trait loci relevant to human NDD phenotypes.

Conclusions:

  • The CC mouse model offers a powerful platform to advance NDD research beyond single-gene, single-background designs.
  • Specific behavioral phenotypes like digging and activity are more amenable to quantifying genetic effects in NDD across diverse genetic backgrounds.