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Plasma Homocysteine Level in Children With Postural Tachycardia Syndrome

Yaqi Li1, Bing He2, Hongxia Li1

  • 1Department of Pediatrics, Peking University First Hospital, Beijing, China.

Frontiers in Pediatrics
|December 19, 2018
PubMed

Insights

Elevated plasma homocysteine (Hcy) levels were found in children with postural tachycardia syndrome (POTS). Higher Hcy correlated with POTS symptom severity and heart rate changes, suggesting Hcy

Area of Science:

  • Cardiology
  • Pediatrics
  • Biochemistry

Background:

  • Postural tachycardia syndrome (POTS) is a condition affecting heart rate regulation.
  • Elevated homocysteine (Hcy) levels are linked to various cardiovascular and neurological conditions.

Purpose of the Study:

  • To evaluate plasma homocysteine (Hcy) levels in children diagnosed with postural tachycardia syndrome (POTS).
  • To explore the correlation between Hcy levels and POTS severity, including symptom scores and heart rate changes.

Main Methods:

  • A case-control study involving 35 children with POTS and 30 healthy controls.
  • Plasma Hcy levels were measured in all participants.
  • Statistical analyses were performed to assess correlations between Hcy levels, symptom scores, and heart rate parameters (ΔHR and ΔHR/sHR × 100%).

Main Results:

  • Children with POTS exhibited significantly higher plasma Hcy levels compared to healthy controls (P < 0.05).
  • Plasma Hcy levels showed a positive correlation with symptom scores in POTS patients (r = 0.522, P < 0.01).
  • Hcy levels were also positively correlated with changes in heart rate (ΔHR: r = 0.332, P < 0.01) and the rate of heart rate increase (ΔHR/sHR × 100%: r = 0.341, P < 0.01) in all subjects.

Conclusions:

  • Plasma Hcy levels are elevated in pediatric POTS patients.
  • Elevated Hcy is associated with increased symptom severity and autonomic dysfunction in POTS.
  • Homocysteine may play a role in the pathophysiology of POTS in children.

Keywords:
blood pressurechildrenheart ratehomocysteinepostural tachycardia syndrome

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