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Related Experiment Video

Updated: Jan 31, 2026

A Porcine Corneal Endothelial Organ Culture Model Using Split Corneal Buttons
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Corneal endothelial cell dysfunction: etiologies and management.

Sepehr Feizi1

  • 1Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran 16666, Iran.

Therapeutic Advances in Ophthalmology
|December 19, 2018
PubMed
Summary
This summary is machine-generated.

Corneal endothelial cell dysfunction impairs vision. Selective endothelial keratoplasty offers advantages, but donor scarcity drives interest in in vitro expanded corneal endothelial cells for transplantation.

Keywords:
corneal endothelial dysfunctionetiologieshuman corneal endotheliummanagement

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Corneal transparency is vital for vision, maintained by a well-organized corneal endothelium.
  • Endothelial cell dysfunction, from conditions like Fuchs' dystrophy, leads to corneal decompensation.
  • Current treatments involve corneal transplantation, with a shift towards selective endothelial keratoplasty.

Purpose of the Study:

  • To detail the causes and symptoms of human corneal endothelial cell dysfunction.
  • To review current management strategies for corneal endothelial dysfunction.
  • To highlight emerging alternatives like in vitro expanded corneal endothelial cells.

Main Methods:

  • Review of etiologies and clinical manifestations of corneal endothelial dysfunction.
  • Analysis of established and novel therapeutic approaches, including selective endothelial keratoplasty.
  • Exploration of in vitro expansion of human corneal endothelial cells as a sustainable alternative.

Main Results:

  • Selective endothelial keratoplasty (Descemet stripping automated endothelial keratoplasty, Descemet's membrane endothelial keratoplasty) shows improved outcomes over penetrating keratoplasty.
  • Donor cornea supply limitations present a significant challenge in corneal transplantation.
  • In vitro expansion of corneal endothelial cells offers a promising solution to meet the demand for corneal tissue.

Conclusions:

  • Corneal endothelial cell dysfunction requires effective management strategies.
  • Selective endothelial keratoplasty is a preferred surgical option for endothelial dysfunction.
  • In vitro expanded corneal endothelial cells represent a sustainable and viable alternative for treating corneal endothelial dysfunction, addressing donor tissue limitations.