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Pneumonia I: Introduction

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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Interstitial Pneumonia in Psoriasis.

Hironori Kawamoto¹, Hiromichi Hara¹, Shunsuke Minagawa¹

¹Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Mayo Clinic Proceedings. Innovations, Quality & Outcomes

|December 19, 2018

Summary

This summary is machine-generated.

Interstitial pneumonia (IP) affects 2% of psoriasis patients needing systemic therapy. Characteristic CT findings include bilateral lower lobe ground-glass opacity, suggesting a role for the IL-23/IL-17 axis in IP pathogenesis.

Keywords:

CT, computed tomography IL, interleukin IP, interstitial pneumonia KL-6, Krebs von den Lungen-6 PASI, psoriasis area severity index SEC, secukinumab UST, ustekinumab

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

Pulmonary Medicine
Dermatology
Immunology

Background:

Psoriasis is a chronic inflammatory disease.
Interstitial pneumonia (IP) is a group of lung diseases.
The association between psoriasis and IP requires further investigation.

Purpose of the Study:

To explore the relationship between psoriasis and interstitial pneumonia (IP).
To identify characteristic radiographic findings of IP in psoriasis patients.
To investigate the potential role of specific biologic pathways in the development of IP.

Main Methods:

Retrospective analysis of clinical data from 392 psoriasis patients treated with biologic agents (2008-2017).
Evaluation of chest computed tomography (CT) scans performed before treatment.
Assessment of clinical characteristics and radiographic findings.

Main Results:

Interstitial pneumonia (IP) was identified in 8 patients (2%) with psoriasis.
The most common CT finding was bilateral ground-glass and/or irregular linear (reticular) opacity in the lower lung zones.
Five patients treated with anti-interleukin (IL)-12/IL-23 or IL-17 antibodies showed decreased or stable IP activity.

Conclusions:

Interstitial pneumonia (IP) occurs in 2% of psoriasis patients requiring systemic treatment.
Bilateral lower lobe ground-glass and/or irregular linear (reticular) opacity is characteristic of IP in psoriasis patients.
The IL-23/IL-17 axis may be implicated in the pathogenesis of IP associated with psoriasis.