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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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[Urinary biomarkers for chronic kidney disease: a focus on gene transcript]
1Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
Sheng Li Xue Bao : [Acta Physiologica Sinica]
|December 19, 2018
Summary
Finding early biomarkers for chronic kidney disease (CKD) is crucial. Urine analysis, particularly gene transcripts like miRNA and mRNA, offers promising non-invasive biomarkers for CKD detection and management.
Area of Science:
- Nephrology
- Biomarker Discovery
- Molecular Diagnostics
Background:
- Chronic kidney disease (CKD) presents a growing global health challenge.
- Current limitations include a lack of early diagnostic biomarkers and effective treatments.
- Precision medicine necessitates sensitive, non-invasive biomarkers for CKD management.
Purpose of the Study:
- To review recent advancements in urinary biomarker research for CKD.
- To focus on gene transcript biomarkers (miRNA, mRNA) from various urine fractions.
- To discuss challenges and future directions in urinary gene transcript biomarker studies.
Main Methods:
- Review of current literature on urinary biomarkers for CKD.
- Analysis of studies examining urine sediment, supernatant, and extracellular vesicles.
- Focus on gene transcript analysis, including miRNA and mRNA.
Main Results:
- Urine is a rich source of biological information for non-invasive CKD biomarker discovery.
- Gene transcripts (miRNA, mRNA) in urine show significant potential.
- Advances have been made in analyzing different urine components for biomarkers.
Conclusions:
- Urinary gene transcripts represent a promising frontier for early CKD detection.
- Further research is needed to overcome challenges and establish clinical utility.
- Non-invasive urinary biomarkers are key to advancing precision medicine in nephrology.
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