Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Global Regulatory Systems01:28

Global Regulatory Systems

676
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
676
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.8K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.8K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

4.1K
4.1K
Global Climate Change01:50

Global Climate Change

28.9K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
28.9K
Introduction to Global Positioning System01:30

Introduction to Global Positioning System

514
The Global Positioning System (GPS) revolutionized positioning on Earth, providing precise location data through satellite ranging. The GPS system was developed in 1978 by the U.S. Department of Defense  for military use, and it became available for civilian applications in 1983, transforming fields including navigation, fleet management, and time synchronization for telecommunications systems.GPS consists of satellites in medium Earth orbit, about 20,200 kilometers above the surface,...
514
Errors in Global Positioning System01:26

Errors in Global Positioning System

353
Global Positioning System (GPS) technology has revolutionized navigation and positioning, but its accuracy is often compromised by various errors. These errors, stemming from environmental, satellite, and receiver-related factors, require careful mitigation to ensure reliable performance across applications.Atmospheric ErrorsGPS signals travel through the Earth’s ionosphere and troposphere, introducing delays which affect accuracy. The ionosphere is strongly influenced by charged particles,...
353

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aerobic Exercise Attenuates Epidermal Hyperplasia in an Obesity-Associated Psoriasiform Dermatitis Model.

International journal of molecular sciences·2026
Same author

Author reply.

The Journal of dermatology·2025
Same author

Epstein-Barr Virus-Induced 3 Attributes to TLR7-Mediated Splenomegaly.

Immunology·2025
Same author

The treatment effect of endovascular therapy for chronic limb-threatening ischemia with systemic sclerosis.

The Journal of dermatology·2024
Same author

Elevated expression of interleukin-6 (IL-6) and serum amyloid A (SAA) in the skin and the serum of recessive dystrophic epidermolysis bullosa: Skin as a possible source of IL-6 through Toll-like receptor ligands and SAA.

Experimental dermatology·2024
Same author

Topical application of activator protein-1 inhibitor T-5224 suppresses inflammation and improves skin barrier function in a murine atopic dermatitis-like dermatitis.

Allergology international : official journal of the Japanese Society of Allergology·2024
Same journal

Enhanced Stability and Transdermal Delivery of Semaglutide Using an L-Arginine Based Dissolving Microneedle System.

AAPS PharmSciTech·2026
Same journal

The Preparation and Physicochemical Characterization of a Triple Synergistic Nanoplatform Designed for Targeted Subcutaneous Delivery of Sitagliptin with Potential for β-Cell Preservation.

AAPS PharmSciTech·2026
Same journal

Repurposing Non-oncologic Drugs via Targeted Nanocarriers for Cancer Therapy: Mechanisms, Synergistic Combinations, and Clinical Translation.

AAPS PharmSciTech·2026
Same journal

Targeting Permeability Barriers By Strategic Selection of Thiol Containing Coformer for Novel Cocrystals of Metformin.

AAPS PharmSciTech·2026
Same journal

Plume Geometry Matters: Investigating the Contribution of Mass-Based Plume Geometry to Aerosol Delivery Efficiency in pMDIs.

AAPS PharmSciTech·2026
Same journal

Eigenrate-Based Thermodynamic Decomposition of Competing Release Mechanisms in Polymeric Nano- and Microspheres: The MMIR-S Framework with Arrhenius Dual-Population Burst Kinetics and Log-Normal Polydispersity Averaging.

AAPS PharmSciTech·2026
See all related articles

Related Experiment Video

Updated: Jan 31, 2026

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.6K

Global Regulatory Landscape.

Yoshihiro Matsuda1

  • 1Pharmaceuticals and Medical Devices Agency (PMDA), Shin-Kasumigaseki Bldg. 3-3-2, Kasumigaseki, Chiyoda-ku, Tokyo, 100-0013, Japan. matsuda-yoshihiro@pmda.go.jp.

AAPS Pharmscitech
|December 19, 2018
PubMed
Summary
This summary is machine-generated.

Continuous manufacturing (CM) is revolutionizing pharmaceutical production. Regulatory agencies worldwide support CM, fostering dialogue and harmonization for its adoption.

Keywords:
PMDAcontinuous manufacturingregulatory convergenceregulatory harmonization

More Related Videos

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
06:32

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

3.0K
Generation of Human Chimeric Antigen Receptor Regulatory T Cells
10:29

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

2.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.6K
Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
06:32

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

3.0K
Generation of Human Chimeric Antigen Receptor Regulatory T Cells
10:29

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

2.4K

Area of Science:

  • Pharmaceutical manufacturing
  • Chemical engineering
  • Regulatory science

Background:

  • Continuous manufacturing (CM) is an emerging production strategy for pharmaceuticals.
  • Regulatory bodies like the EMA, FDA, and PMDA support CM adoption.
  • Early industry-agency dialogue is encouraged for CM implementation.

Purpose of the Study:

  • To outline the current regulatory environment for pharmaceutical CM.
  • To discuss the ongoing efforts in regulatory harmonization for CM.
  • To provide insights into the global regulatory landscape of CM.

Main Methods:

  • Review of regulatory agency statements and guidances.
  • Analysis of international regulatory harmonization initiatives.
  • Synthesis of current practices and future trends in pharmaceutical CM regulation.

Main Results:

  • Global regulatory agencies actively support the transition to CM.
  • Significant progress has been made in harmonizing regulatory requirements for CM.
  • Opportunities for early engagement with regulatory bodies are available.

Conclusions:

  • The regulatory landscape is favorable for pharmaceutical CM.
  • Harmonization efforts are crucial for widespread CM adoption.
  • Continued collaboration between industry and regulators will drive CM innovation.