Related Experiment Video
Updated: Jan 31, 2026
09:58
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
4.0K
Enterovirus A71 Infection and Neurologic Disease, Madrid, Spain, 2016.
Emerging Infectious Diseases
|December 19, 2018
Summary
Enterovirus infections in children can cause severe neurologic symptoms. Enterovirus A71 was the most common cause in this study, highlighting the need for broader diagnostic testing beyond cerebrospinal fluid.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Virology
Background:
- Enterovirus infections are a significant cause of pediatric neurologic disease.
- Early and accurate diagnosis is crucial for effective management and outcomes.
Purpose of the Study:
- To investigate the clinical presentation, diagnostic findings, and outcomes of enterovirus infections in hospitalized children with neurologic symptoms.
- To identify the most common enterovirus serotypes and their association with specific neurologic conditions.
Main Methods:
- Observational study of 30 pediatric patients with neurologic symptoms and confirmed enterovirus infection.
- Real-time PCR used for enterovirus detection in cerebrospinal fluid, nasopharyngeal aspirate, and anal swabs.
- Enterovirus genotyping performed on a subset of patients.
Main Results:
- Fever, lethargy, myoclonic jerks, and ataxia were common symptoms.
- Enterovirus A71 was the predominant serotype (21/25), particularly in cases of brainstem encephalitis or encephalomyelitis.
- Leukocytosis was observed in patients with severe disease.
Conclusions:
- Enterovirus A71 is a key pathogen in pediatric neurologic disease.
- Diagnostic testing for enterovirus should include nasopharyngeal and anal swabs, not solely cerebrospinal fluid, especially in cases of severe encephalitis or encephalomyelitis.
Related Concept Videos
01:20Infection
12.5K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
12.5K
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K
01:26Stages of Infection
65.2K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.2K
01:25Immunodeficiency Diseases
2.4K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
2.4K
01:26Defense Mechanism Against Infection
9.7K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.7K
01:26Sexually Transmitted Infections
1.1K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.1K