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Biokinetics and dose assessment after iodine intake in a thyroidectomised rat model
Meriem Mezaguer-Lekouaghet1, Maamar Souidi2, Abdewahab Badreddine1
1Centre de Recherche Nucléaire d'Alger (CRNA), Algeria.
Summary
Iodine-131 therapies are common in Algeria. This study evaluated iodine-131
Area of Science:
- Nuclear medicine
- Radiotoxicology
- Radiation protection
Background:
- Iodine-131 (I-131) therapies constitute over 90% of nuclear medicine treatments in Algeria.
- Evaluating long-term effects of I-131 on non-target organs is crucial for enhancing patient radiation safety.
Purpose of the Study:
- To establish biokinetic models for iodine contamination.
- To assess the biological half-life and biodistribution of I-131 in Wistar rats.
- To calculate absorbed doses in key organs for improved radiation protection strategies.
Main Methods:
- Utilized two Wistar rat models: one with a thyroid and one without.
- Determined the biological half-life of iodine.
- Conducted a biodistribution study of iodine activity across 15 organs and tissues.
- Calculated absorbed doses in relevant organs using RODES software.
Main Results:
- Established biokinetic models for iodine contamination in rats.
- Quantified the biological half-life and biodistribution patterns of iodine.
- Determined organ-specific absorbed radiation doses.
Conclusions:
- The study provides essential data for refining radiation protection measures in I-131 therapy.
- Understanding iodine biokinetics is key to minimizing risks to non-target organs.
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