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Updated: Jan 31, 2026
A Non-Invasive Method for Generating the Cyclic Loading-Induced Intra-Articular Cartilage Lesion Model of the Rat Knee
Published on: July 5, 2021
[Predicting and preventing the development of post-traumatic gonarthrosis with intra-articular bone fractures of the
1Department of Traumatology and Orthopedics Kursk State Medical University, Kursk, Russia.
Objective:
To develop a program for the prediction and prevention of post-traumatic osteoarthritis of the knee joints.
Material And Methods:
For the period 2012-2017. 155 patients were examined in the traumatology departments of the Municipal Hospital No.4. This group of patients was hospitalized with various intraarticular lesions of the knee joints. Patients with injuries to the condyles of the femur were 54, with fractures of the proximal metaepiphysis of the tibia of different severity, 101 patients were examined. All the patients in the study group underwent a special questionnaire with a view to a detailed study of the risk factors for post-traumatic gonarthrosis, as well as studies of the possible effect of genetic components (ribosomal gene activity) in the pathogenesis of the disease. All patients in the study group were divided into three groups, posttraumatic gonarthrosis, based on prognostically valuable factors: the first group (low risk), the second group (probable development of the disease), the third group (in soky risk). A follow-up examination of patients, to assess the development of a disease, was performed 1 and 3 years after the operation.
Results:
No patients were diagnosed with osteoarthritis in the first group of clinical and new X-ray signs after a year of examination. In the second and third groups there was an appearance of initial radiographic signs in 9.6 and 16% of patients, respectively, in the absence of a significant clinical picture of osteoarthritis. Two years later, the development and progression of osteoarthritis in the groups was observed in 14.7, 36.8 and 68% cases, respectively, with clinical manifestations of the disease. Three years later, the number of patients with post-traumatic arthrosis in the first group practically did not change (17.9%), and in the second and third groups the development of gonarthrosis occurred almost in all cases.
Conclusion:
Intra-articular fractures of the condyles of the femoral and tibia bones, with the most 'favorable' prognosis, lead to the development of post-traumatic osteoarthritis of the knee joint in 14.7%, with a probable prognosis, osteoarthritis developed in 47.6% of cases, and with unfavorable prognosis.
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