Elevated serum CCL4/MIP-1β levels in postmenopausal osteoporosis patients are linked with disease severity
Xian-Wen Yang1, Fei Wang2, Ru-Zi Qin1
1Guangdong Provincial Corps Hospital of Chinese People's Armed Police Forces, Guangzhou Medical University, GuangZhou, GuangDong Province, 510006, PR China.
Aim:
To investigate if the serum CC motif ligand 4 (CCL4) levels are linked to disease severity in patients with postmenopausal osteoporosis (PMOP).
Patients & Methods:
We enrolled 66 PMOP females, 68 postmenopausal nonosteoporotic women and 67 healthy women of childbearing age. Bone mineral densities were assessed with dual x-ray absorptiometry scans. The Oswestry disability index and the visual analog scale were employed to quantify functional ability and severity of symptoms. Serum CCL4 levels were examined with a quantitative sandwich enzyme-linked immunosorbent assay.
Results:
We observed a significant negative correlation of CCL4 serum levels with bone mineral density. Furthermore, serum CCL4 concentrations were significantly related to the visual analog scale and Oswestry Disability Index scores.
Conclusion:
Serum CCL4 is a potential biomarker to evaluate disease severity in PMOP females.
Related Concept Videos
Freezing Point Depression and Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
X-linked Traits
Elevation of Intermediate Points on Vertical Curves
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
Leveling Effect


