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Puumala Hantavirus Genotypes in Humans, France, 2012-2016

Jean-Marc Reynes, Damien Carli, Damien Thomas

    Emerging Infectious Diseases
    |December 19, 2018
    PubMed

    Insights

    Puumala hantavirus strains in France belong to the Central European lineage. Analysis revealed two distinct clusters based on geographical distribution and specific genetic signatures (Q64 and R64).

    Area of Science:

    • Virology
    • Molecular Epidemiology

    Background:

    • Puumala hantavirus (PUUV) is a significant etiological agent of nephropathia epidemica (NE) in Europe.
    • Understanding the genetic diversity and geographical distribution of PUUV is crucial for disease surveillance and control.

    Purpose of the Study:

    • To genetically characterize Puumala hantavirus strains detected in human samples in France.
    • To investigate the genetic lineage and population structure of PUUV in the studied region.

    Main Methods:

    • Nucleoprotein (NP) gene sequencing of 77 Puumala hantavirus strains.
    • Phylogenetic analysis to determine genetic lineages and population structure.

    Main Results:

    • All 77 analyzed strains belonged to the Central European lineage of Puumala hantavirus.
    • Two distinct genetic clusters were identified, showing a geographical structure.
    • One cluster was characterized by the Q64 amino acid signature, while the other exhibited the R64 signature in the NP gene.

    Conclusions:

    • The Puumala hantavirus population in France is predominantly of the Central European lineage.
    • Geographical structuring and specific genetic signatures (Q64/R64) highlight localized transmission patterns and potential evolutionary divergence within France.
    Keywords:
    FrancePuumala virusgenotypehantavirushumansorthohantavirusviruseszoonoses

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