Related Experiment Video

Updated: Jan 31, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
06:32

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

8.5K

Personalised fractional flow reserve: a novel concept to optimise myocardial revascularisation

Rebecca C Gosling1, Paul D Morris, Patricia V Lawford

  • 1Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|December 19, 2018
PubMed

Insights

This study introduces maximal achievable fractional flow reserve (FFRmax), a personalized metric to assess percutaneous coronary intervention (PCI) outcomes. FFRmax provides a more realistic evaluation of flow restoration than standard FFR, potentially avoiding unnecessary procedures.

Area of Science:

  • Cardiovascular medicine
  • Interventional cardiology
  • Physiological modeling

Background:

  • Fractional flow reserve (FFR) quantifies coronary stenosis severity but rarely reaches physiological normality (1.00) post-percutaneous coronary intervention (PCI).
  • Diffuse coronary disease presents challenges for achieving optimal FFR outcomes with PCI.
  • A personalized assessment of achievable physiological results is needed.

Purpose of the Study:

  • To describe a method for calculating vessel-specific maximal achievable FFR (FFRmax).
  • To provide a personalized assessment of what PCI can achieve in terms of FFR.
  • To compare FFRmax with post-PCI FFR measurements.

Main Methods:

  • Three-dimensional (3D) coronary anatomy was reconstructed from angiographic images of 71 patients (100 arteries).
  • An ideal intervention model was used to calculate FFRmax, representing the FFR after complete stenosis removal.
  • Personalized FFR (FFRpers) was calculated as measured FFR/FFRmax.

Main Results:

  • The mean FFRmax was 0.92 (±0.04).
  • Post-PCI FFR was significantly lower than FFRmax (mean difference 0.04, p<0.001).
  • FFRpers was significantly higher than measured FFR (mean difference 0.06, p<0.001), indicating FFR overestimates achievable flow restoration.

Conclusions:

  • Maximal achievable FFR (FFRmax) can be determined pre-PCI.
  • This approach offers a more realistic physiological benefit assessment of PCI.
  • FFRmax may help prevent unnecessary interventions by setting achievable goals.
Abstract

More Related Videos

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice05:07

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice

Published on: August 25, 2023

1.9K
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.7K

Related Concept Videos

Self-Concept01:19

Self-Concept

Self-concept is the cognitive and emotional understanding individuals hold about their identity. It evolves through various developmental stages, beginning in infancy and maturing as children grow. This concept influences how individuals perceive their abilities, interact with others, and manage challenges throughout life.
Infancy and Emerging Recognition
During infancy, self-concept is virtually nonexistent. Babies do not distinguish themselves as separate entities and often mistake their...
1.7K
Concepts and Prototypes01:24

Concepts and Prototypes

The human nervous system handles vast amounts of information by translating sensory stimuli into neural impulses, which the brain processes, creating thoughts expressed through language or stored as memories. The brain also synthesizes information from emotions and memories, which significantly influence thoughts and behaviors. This intricate process creates a comprehensive mental picture.
The brain organizes this information using concepts, which are mental categories grouping linguistic data,...
547
Formula Mass and Mole Concepts of Compounds02:56

Formula Mass and Mole Concepts of Compounds

Formula Mass of Covalent Compounds
81.2K
Basic Concept01:28

Basic Concept

Engineering mechanics is a branch of engineering that studies motion and the forces acting on objects. It is a fundamental subject and forms the basis of many other engineering disciplines. Length, time, mass, and force are some basic concepts in engineering mechanics.
Length, which measures the distance traveled by an object, is a fundamental concept in engineering mechanics. We use coordinates relative to a reference point to describe the distance. Length not only helps to describe the...
6.2K
Concept of Pressure at a Point01:15

Concept of Pressure at a Point

The concept of pressure at a point in a fluid establishes that pressure within a fluid is uniform in all directions at a specific location. This uniformity occurs because fluid molecules exert force evenly across any point due to their random motion and continuous collisions within the fluid. Pressure at a point is determined by the surrounding fluid molecules and is influenced by factors like depth and density, rather than by shape or orientation.
In a fluid at rest, pressure acts equally in...
751
Understanding Self-Concept01:20

Understanding Self-Concept

The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
278