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Updated: Jan 31, 2026

Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation
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Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation

Published on: June 3, 2018

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Long-term results and durability of the CoreValve transcatheter aortic bioprosthesis: outcomes beyond five years

Roberta Antonazzo Panico1, Cristina Giannini, Marco De Carlo

  • 1Vascular and CardioThoracic Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|December 19, 2018
PubMed

Insights

The third-generation CoreValve device demonstrated good durability for high-risk patients undergoing transcatheter aortic valve implantation (TAVI) over seven years. Structural valve deterioration and bioprosthetic valve failure rates were low, indicating long-term efficacy.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Biomaterials Science

Background:

  • Transcatheter aortic valve implantation (TAVI) is a key treatment for high-risk patients with severe aortic stenosis.
  • Assessing long-term bioprosthetic valve durability is crucial for patient management and device development.

Purpose of the Study:

  • To evaluate the seven-year durability of the third-generation CoreValve bioprosthesis in high-risk patients.
  • To identify predictors of heart failure rehospitalisation and all-cause mortality post-TAVI.

Main Methods:

  • Prospective single-centre registry of 278 high-risk TAVI patients (2007-2013).
  • Utilized Cox proportional hazards model for survival analysis.
  • Echocardiographic follow-up assessed valve function, paravalvular leak, and structural valve deterioration.

Main Results:

  • Median follow-up of survivors was 6.8 years.
  • Low cumulative incidences of structural valve deterioration (3.6%) and bioprosthetic valve failure (2.5%).
  • Mild paravalvular leak and stable pressure gradients observed throughout follow-up.

Conclusions:

  • The CoreValve bioprosthesis exhibits favorable durability up to seven years post-TAVI.
  • Despite high overall mortality in this elderly cohort, the device provides a durable solution for aortic stenosis.
Abstract

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