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Updated: Jan 31, 2026

Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport

Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport

Published on: June 28, 2014

To BBB or Not to BBB?

Jean-Leon Thomas¹, Anne Eichmann²

¹Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, Paris, France; Department of Neurology, Yale University School of Medicine, New Haven, CT 06511, USA.

Developmental Cell

|December 19, 2018

Summary

This summary is machine-generated.

Pituicytes, a type of glial cell, control blood vessel permeability in zebrafish embryos by secreting factors that open junctions and blocking signals that would normally keep them closed.

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Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

The neurohypophysis is a critical brain region with unique vascular properties.
Endothelial cell permeability regulates the passage of molecules into the brain.

Purpose of the Study:

To investigate the role of pituicytes in regulating endothelial cell permeability in the zebrafish neurohypophysis.

Main Methods:

Utilized zebrafish embryo models.
Investigated cellular and molecular mechanisms of endothelial permeability.

Main Results:

Demonstrated that pituicytes, a subtype of astroglia, actively drive endothelial cell permeability.
Identified secretion of Vegfa/Tgfβ3 as key factors promoting fenestrae formation.
Showed repression of anti-inflammatory retinoic acid signaling, which normally induces tight junctions.

Conclusions:

Pituicytes play a crucial role in modulating neurohypophyseal vascular permeability.
The findings reveal a novel mechanism involving secreted factors and signaling pathway repression.