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Updated: Jan 31, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
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Published on: October 11, 2014

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[50 Years ago: First Successful Treatment of Acute Allograft Rejection after a Human Heart Transplantation]

Walter G Land

    Deutsche Medizinische Wochenschrift (1946)
    |December 19, 2018
    PubMed

    The first clinical use of the "Munich antilymphocyte globulin" (ALG) at the occasion of the first successful human heart transplantation is briefly described. The cardiac transplantation was carried out by Christiaan Barnard and his team in Cape Town, South Africa, in 1968. The patient developed an acute allograft rejection which could be successfully reversed within three weeks using the intravenous administration of ALG. This event can be regarded as the beginning of a success story of ALG in its use as a powerful immunosuppressive agent in all categories of clinical organ transplantation.

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