Immunotherapy for gastroenterological cancer

After the paradigm shift happened in malignant melanoma, the immune checkpoint inhibi- tors have been developed all over the world in the many types of cancer not the exception of the gastroenterological cancer. The authors showed a comprehensive review of the literature and update on the use of anti-CTLA-4, anti-PD-1 and anti-PD-LI therapy in the area of gastro- enterological cancer. The clinical evidence of the immune checkpoint inhibitors in gastroen- terological cancer remains limited, although the light come in this cancer type and immuno- therapy could play an important role in the year to come.