Coronary Vasculature in Cardiac Development and Regeneration

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Subir Kapuria1, Tyler Yoshida2,3, Ching-Ling Lien4,5,6

  • 1The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. skapuria@chla.usc.edu.

Journal of Cardiovascular Development and Disease
|December 20, 2018
PubMed

Insights

Understanding coronary vessel development and regeneration is key for heart health. This review explores coronary vessel formation, cell origins, signaling pathways, and heart regeneration mechanisms in zebrafish.

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Functional coronary circulation is vital for heart health in vertebrates.
  • Coronary diseases pose significant health risks.
  • Knowledge gaps exist regarding coronary vessel development and its role in heart regeneration.

Purpose of the Study:

  • To provide a comprehensive review of coronary vessel formation and heart regeneration.
  • To explore the evolutionary perspective of coronary vessel development.
  • To summarize critical signaling pathways and molecular mechanisms involved.

Main Methods:

  • Literature review focusing on evolutionary, cellular, and molecular aspects.
  • Analysis of signaling pathways regulating coronary vessel development.
  • Examination of heart regeneration mechanisms in zebrafish.

Main Results:

  • Early revascularization is crucial for effective heart regeneration.
  • Detailed discussion on cell origins of coronary endothelial and perivascular cells.
  • Summary of key signaling pathways in coronary vessel development.

Conclusions:

  • Zebrafish serve as a valuable model for studying heart regeneration and coronary systems.
  • Further research into molecular mechanisms can advance therapeutic strategies for heart disease.

Keywords:
coronary vesselsendothelial cellsheart regenerationperivascular cells

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