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Selenium and Type 2 Diabetes: Systematic Review.

Lindsay N Kohler1,2, Janet Foote3, Connor P Kelley4

  • 1Department of Health Promotion Sciences, Mel and Enid College of Public Health, University of Arizona, Tucson, AZ 85724, USA. lschulz@email.arizona.edu.

Nutrients
|December 20, 2018
PubMed
Summary
This summary is machine-generated.

Selenium (Se) shows conflicting associations with type 2 diabetes (T2D) risk. Observational studies suggest a link, but randomized trials do not confirm this increased risk for selenium supplementation.

Keywords:
glucoseinsulin resistancereviewseleniumselenium supplementationtype 2 diabetes

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Area of Science:

  • Nutritional Biochemistry
  • Metabolic Disorders
  • Epidemiology

Background:

  • Conflicting evidence exists regarding selenium's role in type 2 diabetes (T2D) development.
  • Understanding this relationship is crucial for public health and nutritional guidelines.

Purpose of the Study:

  • To systematically review and meta-analyze existing evidence on the association between selenium and T2D.
  • To reconcile discrepancies between observational studies and randomized controlled trials.

Main Methods:

  • Systematic literature search of PubMed, Embase, and Scopus databases.
  • Inclusion of 16 studies (13 observational, 3 RCTs) following PRISMA guidelines.
  • Meta-analysis of observational data and RCTs on selenium and T2D risk.

Main Results:

  • Observational studies indicated a positive association between selenium levels and T2D risk (summary OR = 2.03, 95% CI 1.51–2.72).
  • Randomized clinical trials of selenium supplementation did not show an increased risk of T2D (OR = 1.18, 95% CI 0.95–1.47).

Conclusions:

  • Discrepancies between observational and trial data suggest potential confounding in observational studies.
  • Further research is needed to clarify selenium's effects on glucose metabolism and T2D risk.