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Updated: Jan 31, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects
Michele Angela Rodrigues1, Dawidson Assis Gomes2,3, Michael Harris Nathanson4
1Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA. michele.rodrigues@yale.edu.
Abstract:
Calcium (Ca2+) is a versatile second messenger that regulates a number of cellular processes in virtually every type of cell. The inositol 1,4,5-trisphosphate receptor (ITPR) is the only intracellular Ca2+ release channel in cholangiocytes, and is therefore responsible for Ca2+-mediated processes in these cells. This review will discuss the machinery responsible for Ca2+ signals in these cells, as well as experimental models used to investigate cholangiocyte Ca2+ signaling. We will also discuss the role of Ca2+ in the normal and abnormal regulation of secretion and apoptosis in cholangiocytes, two of the best characterized processes mediated by Ca2+ in this cell type.
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