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Updated: Jan 31, 2026
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In Ovo Electroporation in the Chicken Auditory Brainstem
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Brainstem gliomas in pregnancy: a systematic review†
Adam Rosen1,2, Valerie Anderson3, Eduard Bercovici4
1Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Summary
Brainstem gliomas in pregnancy present diagnostic challenges but prompt MRI and treatment, including surgery and radiation, are crucial. While maternal mortality is high, neonatal outcomes are generally favorable, with preterm birth being the main risk.
Area of Science:
- Neuro-oncology
- Maternal-fetal Medicine
- Systematic Review
Background:
- Brainstem gliomas are rare neoplasms.
- Diagnosis and management during pregnancy pose unique challenges.
- This study reviews existing literature and presents a case.
Observation:
- Reviewed 17 pregnancies in 16 women with brainstem glioma.
- Median gestational age at presentation was 23 weeks.
- Neurologic deficits were common; MRI confirmed all diagnoses.
Findings:
- Surgical resection and radiation therapy were safely performed during pregnancy.
- Maternal mortality was high (50%), with deaths occurring during or shortly after pregnancy.
- Pregnancy losses included termination and miscarriage; live births showed a risk of preterm birth.
Implications:
- Neurologic deficits in pregnant women warrant urgent investigation for brainstem glioma.
- Magnetic resonance imaging is the preferred diagnostic tool.
- Treatment, including surgery and radiation, should not be delayed due to pregnancy, as outcomes are favorable despite maternal risks.
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