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Updated: Jan 31, 2026

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
Published on: November 22, 2024
Mass drug administration for malaria elimination: do we understand the settings well enough?
Manuel W Hetzel1,2, Blaise Genton3,4,5
1Swiss Tropical and Public Health Institute, P.O. Box, 4002, Basel, Switzerland. manuel.hetzel@swisstph.ch.
Abstract:
Mass drug administration (MDA) of antimalarials has re-emerged as a recommended tool for interrupting malaria transmission, but evidence from low endemicity settings is scarce. A trial in Zanzibar found that two rounds of MDA made no significant impact on malaria incidence, and many questions on the optimal mode and setting for implementing MDA remain unanswered. A more thorough understanding of local sources and drivers of transmission, and a better toolbox for evaluating interventions in near-elimination settings are essential.Please see related research article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1202-8 .
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