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Updated: Jan 31, 2026

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
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Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Published on: June 17, 2016

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Large-scale pharmacogenomics based drug discovery for ITGB3 dependent chemoresistance in mesenchymal lung cancer

Soon-Ki Hong1, Haeseung Lee2, Ok-Seon Kwon1

  • 1College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.

Molecular Cancer
|December 20, 2018
PubMed

Insights

Researchers identified epithelial-mesenchymal transition as a cause of chemoresistance and found that targeting ITGB3 can overcome this resistance. Atorvastatin was identified as a potential drug to repurpose for treating chemoresistant cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Chemoresistance in cancer is a major clinical challenge, often linked to targets with poor druggability.
  • Systematic analysis of cancer cell transcriptomes and drug-response data is crucial for identifying resistance mechanisms and predicting therapeutic strategies.

Discussion:

  • Epithelial-mesenchymal transition (EMT) is a common mechanism underlying resistance to chemotherapeutic drugs.
  • Integrin beta 3 (ITGB3) expression correlates with both drug resistance and mesenchymal phenotype, making it a potential target to overcome chemoresistance.
  • ITGB3 depletion sensitizes cancer cells to chemotherapy by modulating the NF-κB signaling pathway.

Key Insights:

  • ITGB3 is identified as a promising target to overcome chemoresistance.
  • Depletion of ITGB3 enhances sensitivity to conventional chemotherapeutic drugs.
  • In silico screening identified atorvastatin as a drug repurposing candidate for chemoresistant cancers by mimicking ITGB3 knockdown effects.

Outlook:

  • The study presents an alternative drug screening approach for undruggable targets by mimicking transcriptome-level changes.
  • Atorvastatin shows potential for repurposing to combat chemoresistance.
  • Further research can explore the therapeutic efficacy of atorvastatin in combination with conventional chemotherapies.
Keywords:
AtorvastatinBiomarkerChemoresistanceDrug repurposingITGB3Mesenchymal cancerNF-κBPharmacogenomicsSystems pharmacology

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