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The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection

Guojin Ou1,2,3,4, Haixia Xu3,4, Hao Yu3,4

  • 1Department of Laboratory Medicine, West China Second University Hospital, Chengdu, Sichuan, China.

Journal of Translational Medicine
|December 20, 2018
PubMed

Insights

Certain HLA-DQB1 alleles are linked to hepatitis B virus (HBV) infection risk and chronic infection. HLA-DQB1 typing can identify individuals with higher susceptibility to HBV infection or chronic disease progression.

Area of Science:

  • Immunogenetics
  • Hepatology
  • Virology

Background:

  • Hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and hepatocellular carcinoma.
  • Polymorphisms in the HLA-DQB1 gene are recognized as significant factors influencing HBV infection outcomes.

Purpose of the Study:

  • To investigate the association between specific HLA-DQB1 alleles and susceptibility to HBV infection.
  • To explore the relationship between HLA-DQB1 alleles and the clearance or chronicity of HBV infection.

Main Methods:

  • Case-control study involving 256 HBV carriers and 433 healthy controls.
  • High-resolution HLA-DQB1 typing and measurement of cytokine levels (IFN-γ, IL-4, IL-10) and DQB1 mRNA expression.
  • Meta-analysis of existing case-control studies on HLA-DQB1 and HBV infection.

Main Results:

  • HLA-DQB1*06:03 demonstrated a protective effect against HBV infection.
  • Specific alleles like HLA-DQB1*04:01, *05:02, *05:03, and *06:01 were identified as risk factors for HBV susceptibility.
  • Alleles such as HLA-DQB1*05:01, *06:03, and *06:04 were associated with protection against HBV infection.

Conclusions:

  • HLA-DQB1 typing can identify individuals at increased risk for HBV infection and chronic HBV infection.
  • Specific HLA-DQB1 alleles are significantly associated with HBV infection susceptibility, clearance, and chronicity, offering potential targets for risk stratification.
Abstract

Keywords:
HBV susceptibilityHLA-DQB1Spontaneous clearancemRNA expression

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