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Updated: Jan 31, 2026
06:15
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
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Tumour treating fields in a combinational therapeutic approach.
Joshua Branter1, Surajit Basu2, Stuart Smith1
1Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK.
Oncotarget
|December 20, 2018
Summary
Tumour Treating Fields (TTFields) offer a novel, non-invasive approach for Glioblastoma multiforme (GBM) treatment. Combining TTFields with other therapies shows synergistic effects, potentially improving patient outcomes beyond the current standard of care.
Area of Science:
- Oncology
- Biophysics
- Medical Technology
Background:
- The standard treatment for newly diagnosed Glioblastoma multiforme (GBM) has not evolved since 2005, involving surgery, radiation, and Temozolomide.
- Tumour Treating Fields (TTFields), a non-invasive therapy using electric fields, is now FDA-approved for recurrent and newly-diagnosed GBM.
- TTFields targets actively dividing cancer cells by inducing mitotic arrest and cell death, with minimal overlapping toxicities.
Purpose of the Study:
- To review the current literature on combining TTFields with various cancer treatment modalities.
- To explore the potential synergistic and additive effects of TTFields in combination therapies for GBM.
Main Methods:
- Literature review of studies investigating TTFields in combination with alkylating agents, radiation, anti-angiogenics, mitotic inhibitors, immunotherapies, and novel agents.
- Analysis of observed effects, including synergistic and additive outcomes, and combination strategies.
Main Results:
- TTFields demonstrates potential for combination therapy due to its distinct mechanism and low toxicity profile.
- Observed synergistic and additive effects when TTFields are combined with various therapeutic agents.
- Identified strategies for effectively combining TTFields with other treatments.
Conclusions:
- TTFields represent a promising addition to GBM treatment, particularly in combination regimens.
- Combinatorial approaches involving TTFields may enhance therapeutic efficacy and improve outcomes for GBM patients.
- Further research into combination strategies is warranted to optimize treatment protocols.
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