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Updated: Jan 31, 2026

Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells
Published on: June 1, 2018
Bracketing phenogenotypic limits of mammalian hybridization
Yoland Savriama1, Mia Valtonen1,2, Juhana I Kammonen3
1Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, 00014 Helsinki, Finland.
Mammalian hybridization can occur between phenotypically disparate species, even those with significant genetic distance. This study of grey and ringed seals reveals predictable hybrid morphology and wild introgression, suggesting broader potential for hybridization.
Area of Science:
- Paleontology
- Evolutionary Biology
- Genetics
Background:
- Genetic analyses increasingly reveal hybridization and introgression in mammalian species.
- Fossil identification relies on morphology when genetic material is absent, necessitating the study of intermediate forms.
- Cranio-dental fossils are crucial for mammalian paleontology and identifying hybrid specimens.
Purpose of the Study:
- To assess the potential for extreme mammalian hybridization by examining a grey and ringed seal hybrid.
- To analyze the genetic and morphological distinctiveness of grey and ringed seals.
- To determine the feasibility of identifying hybrids morphologically and investigate wild hybridization.
Main Methods:
- Comparative genetic analysis of grey and ringed seals.
- Morphological and developmental analysis of cranio-dental material from a captive hybrid.
- Genetic analysis of parent populations to detect wild introgression.
Main Results:
- The genetic distance between grey and ringed seals is substantial, exceeding the human-Neanderthal distance.
- Despite genetic distance, morphological analyses show the hybrid is a predictable intermediate between the disparate parent species.
- Genetic analysis of parent populations confirmed introgression in the wild, indicating hybridization extends beyond captivity.
Conclusions:
- Mammalian hybridization has a considerable potential even between phenotypically disparate taxa.
- Morphological analysis of cranio-dental fossils can identify hybrids from phenotypically extreme parent species.
- Hybridization and introgression are not limited to captive individuals and occur in wild populations.
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