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From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?

Anne-Laure Bonnet1,2, Catherine Chaussain1,2, Isabelle Broutin3

  • 1EA 2496 Orofacial Pathologies, Imaging and Biotherapies, Dental School Faculty, University Paris Descartes and Life Imaging Platform (PIV), Montrouge, France.

Frontiers in Medicine
|December 20, 2018
PubMed

Insights

Vasorin (VASN), a glycoprotein, is vital for early mouse development and may serve as a biomarker for kidney disease and cancer. Further research is needed to understand its role in pathophysiology.

Area of Science:

  • Biochemistry
  • Developmental Biology
  • Molecular Biology

Background:

  • Vasorin (VASN) is a transmembrane glycoprotein identified in 1988.
  • It is expressed during early mouse development and in adult tissues like the kidney, aorta, and brain.
  • Vasn knockout mice exhibit lethality within three weeks due to unknown causes.

Purpose of the Study:

  • To review current knowledge on vasorin (VASN).
  • To discuss the implications of VASN in organ pathophysiology.
  • To explore VASN's potential as a biomarker for nephropathies and tumorigenesis.

Main Methods:

  • Literature review of existing studies on vasorin.
  • Analysis of VASN expression patterns in development and adult tissues.
  • Investigation of VASN's interactions with signaling pathways like TGF-β and Notch1.

Main Results:

  • Vasn knockout mice demonstrate early lethality, suggesting a critical developmental role.
  • VASN is implicated as a potential biomarker for kidney diseases and cancer.
  • Interactions with TGF-β and Notch1 pathways provide insights into VASN functions.

Conclusions:

  • Vasorin (VASN) plays a significant role in early development and postnatal organ homeostasis.
  • Understanding VASN's function is crucial for its application as a diagnostic biomarker.
  • Further research is warranted to elucidate the precise mechanisms underlying VASN's role in pathophysiology.
Keywords:
Notch1Slitl2TGF-βbiomarkerdevelopmentpathophysiology

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