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Cascade laser sensing concepts for advanced breath diagnostics.

Erhan Tütüncü1, Boris Mizaikoff2

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Analytical and Bioanalytical Chemistry
|December 20, 2018
PubMed
Summary

Exhaled breath analysis (EBA) offers non-invasive disease diagnostics. Cascade laser spectroscopy (CLS) provides a sensitive, selective method for real-time monitoring of breath biomarkers at the point-of-care.

Keywords:
Exhaled breath analysisGas sensingInfrared sensorsInterband cascade laserLaser spectroscopyMid-infraredQuantum cascade laser

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Area of Science:

  • Medical Diagnostics
  • Analytical Chemistry
  • Spectroscopy

Background:

  • Exhaled breath analysis (EBA) enables non-invasive disease diagnostics and real-time monitoring.
  • Identifying trace-level biomarkers in breath presents significant analytical challenges.
  • Conventional methods like GC-MS struggle with the low concentrations (ppb) of target molecules.

Purpose of the Study:

  • To review the current status and potential of cascade laser spectroscopy (CLS) for exhaled breath diagnostics.
  • To highlight advancements in CLS instrumentation and applications for breath analysis.
  • To discuss future prospects and challenges in CLS-based breath diagnostics.

Main Methods:

  • Focus on cascade laser spectroscopy (CLS) as a novel analytical technique for breath analysis.
  • Discuss CLS advantages: high molecular selectivity, sensitivity, and potential for compact, user-friendly sensors.
  • Review recent developments in CLS instrumentation for trace gas sensing.

Main Results:

  • CLS offers sensitive and molecularly selective detection of exhaled breath components.
  • The technology enables near real-time response and label-free detection.
  • CLS shows promise for point-of-care (POC) feasibility in breath diagnostics.

Conclusions:

  • Cascade laser spectroscopy is a promising technology for sensitive and selective exhaled breath analysis.
  • CLS advancements support the development of point-of-care diagnostic tools.
  • Further development is needed to overcome challenges and realize the full potential of CLS in breath diagnostics.