Related Experiment Video

Updated: Jan 31, 2026

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

7.3K

Value of Cardiac Magnetic Resonance Fractal Analysis Combined With Myocardial Strain in Discriminating Isolated Left

Tian Zheng1, Xiaohai Ma2, Shuhao Li1

  • 1Department of Radiology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.

Journal of Magnetic Resonance Imaging : JMRI
|December 20, 2018
PubMed

Insights

Fractal analysis quantitatively measures left ventricular trabeculation, aiding differentiation between left ventricular noncompaction (LVNC) and dilated cardiomyopathy (DCM). Combining fractal dimension with myocardial strain offers a novel biomarker for distinguishing these conditions.

Area of Science:

  • Cardiovascular Imaging
  • Biomedical Engineering
  • Quantitative Analysis

Background:

  • Distinguishing isolated left ventricular noncompaction (LVNC) from dilated cardiomyopathy (DCM) can be challenging due to excessive trabeculation in both conditions.
  • Fractal dimension (FD) offers a quantitative method to assess myocardial trabeculation extent.

Purpose of the Study:

  • To compare trabeculae features and myocardial strain using cardiac MRI between LVNC and DCM patients.
  • To evaluate the diagnostic utility of fractal analysis and myocardial strain in differentiating LVNC from DCM.

Main Methods:

  • Cardiac MRI with steady-state free precession cine imaging was performed on 35 LVNC patients, 30 DCM patients, and 20 healthy controls.
  • Left ventricular trabeculation was assessed using a semiautomatic fractal analysis tool.
  • Myocardial deformation was quantified using feature tracking to derive global peak longitudinal strain (GPLS).

Main Results:

  • Max apical FD and mean global FD were significantly higher in the LVNC group compared to the DCM group (P < 0.001).
  • FD values demonstrated good diagnostic accuracy for LVNC, with AUCs of 0.881 for max apical FD and 0.895 for mean global FD.
  • The combination of fractal analysis (FD) and GPLS achieved the highest diagnostic accuracy (AUC = 0.93) for differentiating LVNC from DCM.

Conclusions:

  • Fractal analysis provides a robust quantitative measure of myocardial trabeculation.
  • The integration of fractal analysis with myocardial strain parameters presents a promising novel biomarker for distinguishing LVNC from DCM.
Abstract

Keywords:
cardiac magnetic resonancedilated cardiomyopathyfractal analysisisolated left ventricular noncompactiontissue tracking

More Related Videos

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.8K
Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

3.5K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
566
Stereotypes, Prejudice, and Discrimination02:55

Stereotypes, Prejudice, and Discrimination

Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
95.4K
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
9.3K
Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
1.2K
Three-Dimensional Analysis of Strain01:29

Three-Dimensional Analysis of Strain

Three-dimensional strain analysis is crucial for understanding how materials deform under stress, particularly in elastic, homogeneous materials. This method employs principal stress axes to simplify complex stress states into more understandable forms. Subjected to stress, a small cubic element within a material either expands or contracts along these axes, transforming into a rectangular parallelepiped. This transformation effectively illustrates the material's deformation. The principal...
624
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
708