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Updated: Jan 31, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
ZIF nano-dagger coated gauze for antibiotic-free wound dressing
Yuan Yuan1, Hong Wu, Hongfang Lu
1Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos #04-01, Singapore 138669, Singapore. ygzhang@ibn.a-star.edu.sg.
Abstract:
Nano-dagger coated gauze was bactericidal against both Gram-positive and Gram-negative bacteria, with log reduction >7 for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available Ag gauze, the ZIF-L nano-dagger coated gauze was more biocompatible with a lower haemolytic activity, less cytotoxicity and improved wound healing performance. Animal studies showed that the ZIF-L coated gauze can effectively kill bacteria in a S. aureus wound infection model in mice. This novel nano-dagger coated gauze offers an effective and safe alternative for patients to protect against wound infections. This study demonstrates the first application of a MOF coating as an antibiotic-free wound dressing with potent antimicrobial activity and improved biocompatibility.
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