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Related Concept Videos

Therapeutic Index01:13

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The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
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Types of Errors: Detection and Minimization01:12

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Error is the deviation of the obtained result from the true, expected value or the estimated central value. Errors are expressed in absolute or relative terms.
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Updated: Jan 31, 2026

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Minimally Invasive and Regenerative Therapeutics.

Nureddin Ashammakhi1,2,3,4,5,6, Samad Ahadian1,2,3, Mohammad Ali Darabi1,2,3

  • 1Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, 90095, CA, USA.

Advanced Materials (Deerfield Beach, Fla.)
|December 20, 2018
PubMed
Summary
This summary is machine-generated.

Minimally invasive regenerative therapeutics (MIRET) offer a low-risk, cost-effective approach for tissue regeneration. Advances in biomaterials and bioelectronics enable MIRET for diverse tissues, with ongoing clinical trials showing promise for wider patient applications.

Keywords:
biomaterialsbiomoleculesdeliveryminimally invasivescaffoldstissue regeneration

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Bioengineering

Background:

  • Minimally invasive therapeutics (MIRET) leverage advances in biomaterial synthesis, stem cell biology, bioimaging, microsurgery, and microscale technologies.
  • MIRET encompasses cells, biomaterials, and biomolecules delivered via minimally invasive methods for tissue regeneration.
  • Current regenerative medicine strategies face challenges in delivery efficiency and patient risk, creating a need for improved therapeutic approaches.

Purpose of the Study:

  • To review minimally invasive approaches for delivering regenerative therapeutics into the body.
  • To describe the application of MIRET for treating various tissues and organs.
  • To highlight future perspectives and challenges in the field of MIRET.

Main Methods:

  • Review of current literature on minimally invasive delivery methods for regenerative therapeutics.
  • Analysis of advancements in biomaterial synthesis, stem cell biology, bioimaging, microsurgery, and microscale technologies.
  • Discussion of in vivo tracking, sensing, and stimulation using nano-biomaterials and soft bioelectronic devices.

Main Results:

  • Minimally invasive delivery methods offer high yield, low risk of complications, and reduced costs compared to conventional methods.
  • MIRET has demonstrated potential for regenerating diverse tissues including bone, cartilage, pancreas, cardiac, skeletal muscle, liver, skin, and neural tissues.
  • Sophisticated tracking, sensing, and stimulation methods enhance the development and application of MIRET.

Conclusions:

  • Minimally invasive regenerative therapeutics (MIRET) represent a promising approach for tissue regeneration across various organs.
  • While clinical trials are underway, wider clinical application of MIRET is anticipated.
  • Further research and development are needed to address challenges and fully realize the potential of MIRET in regenerative medicine.