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Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
Published on: October 20, 2023
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Minimally Invasive and Regenerative Therapeutics
Nureddin Ashammakhi1,2,3,4,5,6, Samad Ahadian1,2,3, Mohammad Ali Darabi1,2,3
1Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, 90095, CA, USA.
Advanced Materials (Deerfield Beach, Fla.)
|December 20, 2018
Summary
Minimally invasive regenerative therapeutics (MIRET) offer a low-risk, cost-effective approach for tissue regeneration. Advances in biomaterials and bioelectronics enable MIRET for diverse tissues, with ongoing clinical trials showing promise for wider patient applications.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Bioengineering
Background:
- Minimally invasive therapeutics (MIRET) leverage advances in biomaterial synthesis, stem cell biology, bioimaging, microsurgery, and microscale technologies.
- MIRET encompasses cells, biomaterials, and biomolecules delivered via minimally invasive methods for tissue regeneration.
- Current regenerative medicine strategies face challenges in delivery efficiency and patient risk, creating a need for improved therapeutic approaches.
Purpose of the Study:
- To review minimally invasive approaches for delivering regenerative therapeutics into the body.
- To describe the application of MIRET for treating various tissues and organs.
- To highlight future perspectives and challenges in the field of MIRET.
Main Methods:
- Review of current literature on minimally invasive delivery methods for regenerative therapeutics.
- Analysis of advancements in biomaterial synthesis, stem cell biology, bioimaging, microsurgery, and microscale technologies.
- Discussion of in vivo tracking, sensing, and stimulation using nano-biomaterials and soft bioelectronic devices.
Main Results:
- Minimally invasive delivery methods offer high yield, low risk of complications, and reduced costs compared to conventional methods.
- MIRET has demonstrated potential for regenerating diverse tissues including bone, cartilage, pancreas, cardiac, skeletal muscle, liver, skin, and neural tissues.
- Sophisticated tracking, sensing, and stimulation methods enhance the development and application of MIRET.
Conclusions:
- Minimally invasive regenerative therapeutics (MIRET) represent a promising approach for tissue regeneration across various organs.
- While clinical trials are underway, wider clinical application of MIRET is anticipated.
- Further research and development are needed to address challenges and fully realize the potential of MIRET in regenerative medicine.
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