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The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
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Acute ischemic stroke due to large-vessel occlusion (LVO) causes rapid brain tissue loss. This study reveals highly variable rates of neuron loss per minute, ranging from under 35,000 to over 27 million, highlighting individual differences in stroke progression.

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Area of Science:

  • Neurology
  • Neuroscience
  • Stroke Research

Background:

  • Acute ischemic stroke from large-vessel occlusion (LVO) leads to progressive brain tissue loss.
  • Previous estimates of neuron loss (≈1.9 million/minute) represent averages, masking significant individual variability.

Purpose of the Study:

  • To quantify the distribution and range of brain tissue loss rates in anterior circulation LVO strokes.
  • To analyze the variability in neuronal loss across diverse clinical presentations of LVO stroke.

Main Methods:

  • Retrospective analysis of a prospectively acquired database of anterior circulation LVO stroke patients.
  • Automated software used for ischemic core volume measurement.
  • Calculation of brain tissue element loss rates using established methodology.

Main Results:

  • Studied 415 patients with internal carotid artery or middle cerebral artery (M1) occlusion.
  • Mean ischemic core volume was 50.4 mL; mean time to imaging was 8.7 hours.
  • Neuron loss rates varied dramatically, from <35,000 to >27 million neurons per minute.

Conclusions:

  • Significant variability exists in infarct growth rates in acute ischemic stroke due to proximal LVO.
  • Neuron loss rates range widely, from slow progressors (<35,000/min) to fast progressors (>27 million/min).
  • Mean and median neuron loss rates were 2 million and 0.9 million per minute, respectively.