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Area of Science:

  • Chemical Sciences
  • Biochemistry
  • Materials Science

Background:

  • Proton-coupled electron transfer (PCET) is crucial for energy conversion and catalysis.
  • Understanding PCET mechanisms is vital for developing artificial systems.
  • Recent advancements have focused on bio-inspired and artificial systems.

Purpose of the Study:

  • To review significant mechanistic PCET studies from the past five years.
  • To highlight contributions to understanding and controlling PCET in artificial systems.
  • To provide an outlook on future research directions in PCET.

Main Methods:

  • Review and synthesis of 16 key mechanistic PCET studies.
  • Analysis of bio-inspired systems, including tyrosine-Z mimics and de novo proteins.
  • Examination of PCET in artificial DNA and light-triggered reactions.

Main Results:

  • Significant progress in understanding PCET mechanisms in artificial systems.
  • Demonstration of control over PCET through bio-inspired and de novo designs.
  • Insights into multi-proton transfers and light-triggered PCET reactions.

Conclusions:

  • Mechanistic PCET studies have greatly advanced artificial system development.
  • Future research should focus on further control and application of PCET.
  • Continued exploration of bio-inspired and light-triggered systems is promising.