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Updated: Jan 31, 2026

Activated Cross-linked Agarose for the Rapid Development of Affinity Chromatography Resins - Antibody Capture as a Case Study
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Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking

Nicholas Vance1, Neelie Zacharias1, Mark Ultsch1

  • 1Research & Early Development , Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.

Bioconjugate Chemistry
|December 20, 2018
PubMed
Summary

A new photoaffinity cross-linking method enables site-specific conjugation of molecules to antibodies without genetic modification. This approach simplifies antibody conjugate preparation and maintains biological activity for targeted therapies.

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