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Updated: Jan 31, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
Published on: June 23, 2013
Sparks Fly in PGE2-Modulated Macrophage Polarization
Fabien Franco1, Mathias Wenes1, Ping-Chih Ho1
1Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Cancer Research, University of Lausanne, Epalinges, Switzerland.
Abstract:
How macrophages convey extracellular signals by bridging metabolism and functions remains unclear. In this issue of Immunity, Sanin et al. (2018) report that prostaglandin E2 (PGE2) treatment in interleukin-4-activated macrophages suppresses mitochondrial membrane potential to control voltage-regulated genes involved in proliferation and immune responses.
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