Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Signs of Puberty01:27

Signs of Puberty

1.5K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.5K
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
Association Areas of the Cortex01:21

Association Areas of the Cortex

9.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.4K
Associative Learning01:27

Associative Learning

1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

2.7K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.7K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paired CRISPR screens identify mitochondrial metabolism and UBE2H as aneuploid-specific dependencies in human cancer cell lines.

bioRxiv : the preprint server for biology·2026
Same author

Treatment Algorithm for Patients with Obesity in India: A Joint Consensus by Endocrine Society of India and Obesity Surgeons Society of India.

Obesity surgery·2026
Same author

Regional distribution and seasonal histomorphology of cell types of pars distalis adenohypophysis of Gaddi goats: A comparative study between the year 2001 and the present in the context of climate change.

Tropical animal health and production·2025
Same author

A clinical-stage oncology compound selectively targets drug-resistant cancers.

bioRxiv : the preprint server for biology·2025
Same author

SAAM-VetNet: an attention-based multi-task framework for animal disease detection and severity grading.

Annals of medicine and surgery (2012)·2025
Same author

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 31, 2026

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.7K

Dandy-Walker variant with precocious puberty: a rare association.

Rajesh Rajput1, Sanat Mishra1, Parul Ahlawat1

  • 1Department of Endocrinology and Medicine Unit, Pt. B D Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

BMJ Case Reports
|December 21, 2018
PubMed
Summary

A rare case report details a 7-year-old boy with central precocious puberty, Dandy-Walker variant, and secondary hypothyroidism. This extremely rare association has not been previously documented in medical literature.

Keywords:
endocrine systemneurologythyroid disease

More Related Videos

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.4K
Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

6.6K

Related Experiment Videos

Last Updated: Jan 31, 2026

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.7K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.4K
Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

6.6K

Area of Science:

  • Pediatric Endocrinology
  • Pediatric Neurology
  • Developmental Biology

Background:

  • Precocious puberty involves early development of secondary sexual characteristics.
  • Dandy-Walker malformation is a congenital brain abnormality affecting the posterior fossa.
  • Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis.

Observation:

  • A 7-year-old male presented with signs of central precocious puberty.
  • Further investigations revealed Dandy-Walker variant (DWV) and secondary hypothyroidism.
  • The patient exhibited premature pubertal development alongside significant neurological and endocrine abnormalities.

Findings:

  • The case highlights an extremely rare co-occurrence of central precocious puberty, Dandy-Walker variant, and secondary hypothyroidism in a pediatric patient.
  • This specific combination of conditions has not been previously reported in existing medical literature.
  • The findings suggest a potential, albeit rare, link between posterior fossa malformations and endocrine dysfunction leading to precocious puberty.

Implications:

  • This case underscores the importance of comprehensive evaluation in children presenting with precocious puberty, considering potential underlying neurological causes.
  • It expands the known spectrum of Dandy-Walker malformation complications.
  • Further research may explore potential shared etiological pathways or mechanisms linking posterior fossa development to the hypothalamic-pituitary-gonadal axis regulation.