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Effects of Space Flight on Mouse Liver versus Kidney: Gene Pathway Analyses
Timothy G Hammond1,2,3, Patricia L Allen4, Holly H Birdsall5,6,7
1Durham VA Medical Center, Medicine Service Line, Durham, NC 27705, USA. hammondoutofoffice@yahoo.com.
International Journal of Molecular Sciences
|December 21, 2018
Summary
Spaceflight alters gene expression in mouse kidneys and livers. Common pathways affected include cellular responses, apoptosis, fat cell differentiation, and protein kinase regulation, offering insights for countermeasures.
Area of Science:
- Space biology
- Molecular biology
- Genomics
Background:
- Understanding gene expression changes during spaceflight is crucial for developing countermeasures.
- Previous transcriptome analyses have not included kidney tissue.
Purpose of the Study:
- To determine genome-wide gene expression changes in kidney and liver tissues of mice after spaceflight.
- To test the hypothesis that common gene expression pathways are activated in multiple tissues in response to spaceflight stimuli.
Main Methods:
- Genome-wide gene expression analysis using gene arrays.
- Comparison of kidney and liver tissue from space-flown mice and ground-based controls.
Main Results:
- Spaceflight induced tissue-specific gene expression changes in both liver and kidney.
- Both tissues showed overexpression of genes related to cellular responses to peptides/hormones/nitrogen compounds, apoptosis, fat cell differentiation, and negative regulation of protein kinase.
Conclusions:
- Spaceflight triggers common molecular pathways in different tissues, including the kidney.
- These findings provide insights into the biological effects of spaceflight and potential targets for countermeasures.
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