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Related Concept Videos

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
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Related Experiment Video

Updated: Jan 31, 2026

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Dental Stem Cells: Current research and future applications.

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Summary
This summary is machine-generated.

Dental stem cells show great promise for regenerative medicine and dentistry, with research rapidly expanding since 2009. While clinical applications are emerging, definitive guidelines for using Stem cells from Human Exfoliated Deciduous teeth (SHED) are still needed.

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Area of Science:

  • Regenerative Medicine
  • Dental Research
  • Stem Cell Biology

Background:

  • Literature on dental stem cells surged post-2009, with over 5,000 new articles and 757 reviews focusing on stem cell types, biomaterials, and banking.
  • 46 clinical trials in periodontics and endodontics have been published in the last nine years, indicating growing clinical interest.

Discussion:

  • Regenerative therapy in endodontics using dental stem cells remains an open question, with current protocols limited to specific cases.
  • The concept of pulp healing as an alternative to conventional endodontic therapy is appealing but not yet widely applicable.
  • The establishment of stem cell banks since 2005 highlights the growing focus on preserving autologous dental stem cells.

Key Insights:

  • Stem cells from Human Exfoliated Deciduous teeth (SHED) are a key focus due to their ease of collection, differentiation potential, and cost-effectiveness compared to umbilical cord cells.
  • Numerous stem cell collection centers now exist globally, particularly in the Northern Hemisphere.
  • Dental stem cells represent a significant resource for both dentistry and broader regenerative medicine, with 25% of stem cell literature involving dental tissue-derived cells.

Outlook:

  • Despite the increasing research and emerging clinical trials, definitive clinical guidelines for dental stem cell applications are still lacking.
  • While no dental treatments currently involve harvested stem cells, this field is rapidly advancing and poised for future breakthroughs.