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Acinetobacter species in laboratory mice: species survey and antimicrobial resistance

Laurentiu Benga1, Andrea T Feßler2, W Peter M Benten1

  • 1Central Unit for Animal Research and Animal Welfare Affairs, University Hospital, Heinrich - Heine - University, Düsseldorf, Germany.

Laboratory Animals
|December 21, 2018
PubMed

Insights

Laboratory mice can carry multidrug-resistant Acinetobacter infections, impacting animal research. This study identified specific Acinetobacter species in mice and assessed their resistance to antibiotics, revealing potential challenges for animal health and research.

Area of Science:

  • Microbiology
  • Veterinary Science
  • Infectious Diseases

Background:

  • The epidemiology of Acinetobacter infections outside hospitals is debated.
  • There's a growing concern regarding multidrug-resistant Acinetobacter in animal populations.

Purpose of the Study:

  • To identify Acinetobacter species isolated from laboratory mice.
  • To determine the antimicrobial susceptibility profiles of these isolates.

Main Methods:

  • Routine microbiological monitoring of laboratory mice.
  • Identification of isolates using 16S rRNA and rpoB gene sequencing.
  • Antimicrobial susceptibility testing using minimal inhibitory concentration (MIC) values.

Main Results:

  • Twelve Acinetobacter isolates were identified, including Acinetobacter radioresistens, Acinetobacter genomospecies 14BJ, Acinetobacter pitii, and Acinetobacter sp. ANC 4051.
  • Most isolates showed low MIC values for many antibiotics.
  • High MIC values were observed for florfenicol, tiamulin, tilmicosin, and cephalothin, suggesting potential therapeutic challenges.

Conclusions:

  • Laboratory mice can be colonized by various Acinetobacter species.
  • These species share similar antibiotic susceptibility profiles.
  • Findings have implications for Acinetobacter epidemiology, animal husbandry, and research involving colonized animals.
Keywords:
Acinetobacteranimalsantibiotic resistancehealth monitoringlaboratory mice

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