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Congo Red and amyloids: history and relationship
Elmira I Yakupova1, Liya G Bobyleva2, Ivan M Vikhlyantsev1,3
1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia yakupova.mira@mail.ru ivanvikhlyantsev@gmail.com bobylev1982@gmail.com.
Bioscience Reports
|December 21, 2018
Summary
Congo Red (CR) staining is a common method for identifying amyloids, but it has limitations. This review highlights CR staining
Area of Science:
- Biochemistry and Molecular Biology
- Histopathology and Diagnostics
Background:
- Congo Red (CR) staining is a widely used qualitative method for identifying amyloid deposits in biological samples.
- Amyloids are protein aggregates implicated in various diseases, necessitating reliable detection methods.
Observation:
- CR staining can produce artifacts and drawbacks, affecting its accuracy both in vitro and in vivo.
- Previous studies indicate that CR staining alone is insufficient for confirming amyloid nature or diagnosing amyloidosis.
Findings:
- This paper reviews the characteristics and limitations of CR staining for amyloid detection.
- Analysis of scientific data reveals CR staining's inadequacy as a sole diagnostic tool for amyloids and amyloidosis.
Implications:
- Researchers should be aware of the pitfalls and caveats associated with CR staining.
- Understanding CR staining's limitations is crucial for selecting appropriate methods in amyloid research and diagnostics.
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