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Cerebral microbleeds: Prevalence and relationship to amyloid burden

Jonathan Graff-Radford1, Hugo Botha2, Alejandro A Rabinstein2

  • 1From the Departments of Neurology (J.G.-R., H.B., A.A.R., K.D.F., R.D.B., M.M.M., R.O.R., D.S.K., R.C.P.), Radiology (J.L.G., J.H., G.M.P., M.L.S., V.J.L., P.V., C.R.J., K.K.), and Health Sciences Research (S.A.P., T.L., M.M.M., R.O.R., W.K.), Mayo Clinic, Rochester, MN. Graff-Radford.Jonathan@mayo.edu.

Neurology
|December 21, 2018
PubMed
Abstract

Insights

Cerebral microbleeds (CMBs) are more common with age. Increased beta-amyloid levels are linked to lobar CMBs, but not deep ones, in this aging study.

Area of Science:

  • Neurology
  • Neuroimaging
  • Gerontology

Background:

  • Cerebral microbleeds (CMBs) are small, asymptomatic hemorrhages in the brain.
  • Their prevalence and relationship with neurodegenerative markers like beta-amyloid are crucial for understanding brain aging.

Purpose of the Study:

  • To determine the prevalence of CMBs in a population-based aging cohort.
  • To investigate the association between CMBs and beta-amyloid burden measured by PET imaging.

Main Methods:

  • Utilized MRI and 11C-Pittsburgh compound B (PiB)-PET scans from the Mayo Clinic Study of Aging (n=1,123).
  • Adjusted for nonparticipation and standardized prevalence to the Olmsted County population.
  • Employed logistic and ordinal logistic regression to analyze the relationship between beta-amyloid load and CMB presence, location, and count.

Main Results:

  • Prevalence of CMBs increased with age, affecting 22.6% of participants.
  • Higher beta-amyloid load (PiB SUVR) was associated with increased odds of CMBs, specifically in lobar regions, not deep ones.
  • Age, hypertension, and beta-amyloid load were linked to higher CMB counts, with greatest density in parietal and occipital regions.

Conclusions:

  • CMB prevalence rises with age.
  • Beta-amyloid deposition is associated with lobar CMBs but not deep CMBs in this population-based sample.

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