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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Chronic Pulmonary Aspergillosis with Pleuroparenchymal Fibroelastosis-like Features

Hisako Kushima1, Hiroshi Ishii1, Yoshiaki Kinoshita1

  • 1Department of Respiratory Medicine, Fukuoka University Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|December 21, 2018
PubMed

Insights

This case study highlights pleuroparenchymal fibroelastosis (PPFE) secondary to aspergillosis. Antifungal treatment improved patient outcomes, suggesting targeted therapy for secondary PPFE.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Radiology

Background:

  • Pleuroparenchymal fibroelastosis (PPFE) is a rare idiopathic lung disease.
  • Idiopathic PPFE often presents with progressive dyspnea and recurrent pneumothorax.

Observation:

  • A 64-year-old male presented with dyspnea, fever, and pneumothorax.
  • Imaging and pathological findings confirmed pleuroparenchymal fibroelastosis.
  • Serum analysis revealed positive antibodies for Aspergillus.

Findings:

  • The patient received voriconazole for suspected aspergillosis.
  • Significant improvement in radiological and physiological findings was observed post-treatment.
  • Diagnosis of secondary PPFE due to aspergillosis was established.

Implications:

  • This case suggests aspergillosis as a potential cause of secondary PPFE.
  • Targeted antifungal therapy may improve prognosis in secondary PPFE.
  • Further research into infectious causes of PPFE is warranted.
Keywords:
chronic pulmonary aspergillosispleuroparenchymal fibroelastosispulmonary function testvoriconazole

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