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Related Experiment Video

Updated: Jan 31, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Chemiplasmonics for high-throughput biosensors.

Achyut J Raghavendra¹, Jingyi Zhu¹, Wren Gregory¹

¹Laboratory of Nano-biophysics, Clemson University, Clemson, SC 29634, USA, rpodila@g.clemson.edu.

International Journal of Nanomedicine

|December 21, 2018

Summary

This summary is machine-generated.

This study introduces a novel chemiplasmonic sensor for enhanced biomarker detection. This method utilizes molecular interactions for improved sensitivity, enabling point-of-care diagnostics with smartphone compatibility.

Keywords:

biosensor fluorescence fullerenes nanosilver surface plasmons

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Last Updated: Jan 31, 2026

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Published on: March 3, 2015

Area of Science:

Plasmonics
Biomarker Detection
Biosensing

Background:

Integrating fluorescence with plasmonics enhances ELISA sensitivity for biomarker detection.
Surface-plasmon-coupled emission offers significant enhancement but requires expensive equipment, limiting high-throughput and point-of-care applications.

Purpose of the Study:

To develop a new chemiplasmonic-sensing paradigm for enhanced emission.
To enable sensitive biomarker detection using affordable optics and instrumentation.

Main Methods:

A novel chemiplasmonic sensing approach was developed using molecular interactions between aromatic dyes and C60 films on silver substrates.
Demonstrated proof-of-concept with rhodamine B-labeled biomolecules, utilizing a laser pointer for excitation and a smartphone camera for detection.

Main Results:

Achieved a 20-fold enhancement in emission from rhodamine B-labeled biomolecules without compromising color.
Successfully demonstrated two model bioassays: a streptavidin-biotin interaction assay and a high-throughput 96-well plate assay for a model antigen, reaching a sensitivity of 6.6 pM.

Conclusions:

Chemiplasmonic sensors can be adapted for point-of-care biomarker detection using smartphones in a normal incidence geometry, eliminating the need for focusing optics.
This technology offers 10-20 times higher sensitivity for high-throughput biomarker screening in a 96-well plate format.