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Prevalence of Enterovirus Meningitis in Children: Report from a Tertiary Center
Izadi Anahita1, Rahbarimanesh Ali Akbar1, Mojtahedi Yousef1
1Bahrami Children Hospital, Tehran University of Medical Science, Tehran, Iran.
Abstract:
Meningitis is the most frequent infection of the central nervous system and viruses aret he most common agents. Enteroviruses are among the most important causative agents. The goal of this study was to determine Coxsackievirus and echovirus infections in children referred to Bahrami Hospital with the diagnosis of meningitis. Forty children with the diagnosis of meningitis, who were referred betweeen January 2017 and February 2018, were evaluated. Forty cases were evaluated. Twenty two (55%) were males and 18 (45%) females (M/F=2.1). The most common age group was 0-4 years and the most cases were admitted in autumn and summer. Entroviruses are the causative agent of meningitis in 26 (65%) cases, including coxsackieviruse type B5 in 18(69%) and coxsackieviruse type B4 in 2(10%). Six meningitis cases were caused by echoviruses(30%). In both coxsackieviruus and echovirus groups, the most frequent age group was less than four year. Among the 26 cases with enterovirus infection, three were admitted in spring (11.5%), eight in summer (30.7%), 10 in autumn (38.4%) and fice (19.2%) in winter. The most common symptoms in cases with entroviruses infection were fever in 26 (100%) patients and nausea/vomiting in 18 (69.2%). Entroviruses are among the most common viral infections leading to meningitis in Iranian children. Rapid diagnosis will result in early and proper treatment.
Insights
Enteroviruses, including Coxsackievirus and echovirus, are common causes of meningitis in Iranian children. Prompt diagnosis of these viral meningitis cases is crucial for effective treatment.
Area of Science:
- Virology
- Pediatric Infectious Diseases
- Neurology
Background:
- Meningitis is a frequent central nervous system infection, with viruses being the most common etiologic agents.
- Enteroviruses represent a significant group of viral pathogens responsible for meningitis.
Purpose of the Study:
- To investigate the prevalence of Coxsackievirus and echovirus infections in children diagnosed with meningitis.
- To identify specific enterovirus types and their clinical associations in pediatric meningitis cases.
Main Methods:
- A retrospective study evaluated 40 children with meningitis admitted to Bahrami Hospital between January 2017 and February 2018.
- Data collected included patient demographics, clinical presentation, and causative viral agents.
Main Results:
- Enteroviruses were identified in 65% of cases (26/40), with Coxsackievirus B5 (18 cases) and B4 (2 cases) being predominant.
- Echoviruses accounted for 30% (6 cases) of the enterovirus-related meningitis.
- Fever (100%) and nausea/vomiting (69.2%) were the most common symptoms associated with enteroviral meningitis.
Conclusions:
- Enteroviruses are a major cause of viral meningitis in Iranian children.
- The findings highlight the importance of early and accurate diagnosis for timely management of pediatric meningitis.
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