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Evaluation the FLAIR Sensitivity and DWI Post-inject in Comparison with Delayed Enhancement T1w for Better Detection

M Hoseinipourasl1, M Zandkarimi1, J Abdolmohammadi2

  • 1Department of Radiology, BSc of Radiology, School of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Journal of Biomedical Physics & Engineering
|December 21, 2018
PubMed
Abstract

Insights

FLAIR post-injection MRI is highly sensitive for detecting active multiple sclerosis (MS) lesions. This technique enhances lesion visualization by suppressing cerebrospinal fluid signals, improving MS diagnosis and monitoring.

Area of Science:

  • Neurology
  • Radiology
  • Immunology

Background:

  • Multiple sclerosis (MS) is a prevalent, chronic autoimmune disease affecting the central nervous system, impacting millions globally.
  • Etiology remains unclear, with proposed factors including immunologic, environmental, infectious, genetic, and sexual influences.
  • MS presents with diverse neurological symptoms and has four main disease types: RRMS, PPMS, SPMS, and progressive-relapsing.

Purpose of the Study:

  • To evaluate the efficacy of FLAIR and DWI MRI sequences in detecting active multiple sclerosis (MS) plaques.
  • To compare the sensitivity of different MRI techniques in identifying active versus non-active MS lesions.

Main Methods:

  • The study involved 32 patients diagnosed with MS plaques.
  • MRI scans were performed using FLAIR and DWI sequences before and after Gadolinium injection.
  • T1-weighted spin-echo (SE) images were acquired with a 15-minute delay post-injection for comparison.

Main Results:

  • FLAIR imaging post-Gadolinium injection demonstrated significantly superior detection of active MS lesions in terms of number and signal intensity.
  • Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) images were capable of differentiating active plaques from non-active lesions without the need for contrast agents.

Conclusions:

  • FLAIR post-injection MRI exhibits the highest sensitivity for detecting active MS lesions.
  • Cerebrospinal fluid (CSF) signal suppression in FLAIR sequences enhances lesion detection by allowing sufficient recovery time for enhanced plaques.
Keywords:
Contrast mediaFLAIRMRIMultiple Sclerosis

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