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Identification of putative drugs for gastric adenocarcinoma utilizing differentially expressed genes and connectivity

Zu-Xuan Chen1, Xiao-Ping Zou2, Huang-Qun Yan2

  • 1Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.

Molecular Medicine Reports
|December 21, 2018
PubMed

Insights

Novel compounds targeting key pathways in gastric adenocarcinoma (GAC) were identified. This research offers potential new treatments for GAC, including methylbenzethonium chloride and alexidine, to improve patient outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Gastric adenocarcinoma (GAC) presents a significant clinical challenge with poor prognosis post-surgery.
  • There is an urgent need for innovative therapeutic strategies to combat GAC progression.

Purpose of the Study:

  • To identify novel compounds that can modulate critical pathways involved in GAC development.
  • To screen for potential anti-GAC agents using bioinformatics approaches.

Main Methods:

  • Differential gene expression analysis using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases.
  • Compound screening via the Connectivity Map (CMap) database.
  • Pathway enrichment analysis using Kyoto Encyclopedia of Genes and Genomes (KEGG).

Main Results:

  • Identified 843 differentially expressed genes (DEGs) in GAC.
  • Enriched 13 significant pathways, including cell cycle and p53 signaling.
  • Screened 78 compounds negatively correlated with DEGs, highlighting seven potential anti-GAC agents, notably methylbenzethonium chloride and alexidine.

Conclusions:

  • This study identified seven candidate compounds, including novel agents for GAC treatment.
  • These findings may offer new therapeutic avenues for improving GAC patient outcomes.
  • Further investigation into the biological mechanisms of these compounds is warranted.
Keywords:
differentially expressed genespathwaysconnectivity mapgastric adenocarcinoma

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