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Oxidized HDL, Adipokines, and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women

Stephen J Peterson1,2, Joseph I Shapiro3, Ellen Thompson3

  • 1Weill Cornell Medical College, New York, New York, USA.

Obesity (Silver Spring, Md.)
|December 21, 2018
PubMed

Insights

Obesity in women is linked to higher levels of inflammatory markers like IL-6 and oxidized HDL (Ox-HDL), and lower levels of beneficial adiponectin and endothelial progenitor cells (EPCs). This suggests a distinct inflammatory profile associated with obesity.

Area of Science:

  • Cardiovascular Science
  • Metabolic Health
  • Inflammation Biology

Background:

  • High body mass index (BMI) is a risk factor for cardiovascular disease.
  • Adipokines, circulating endothelial cells (CECs), and endothelial progenitor cells (EPCs) play roles in metabolic and cardiovascular health.
  • The interplay between BMI, adipokines (IL-6, TNFα, adiponectin), oxidized high-density lipoprotein (Ox-HDL), CECs, and EPCs in obesity is not fully understood.

Purpose of the Study:

  • To investigate the relationship between BMI, adipokines, Ox-HDL, CECs, and EPCs in females with obesity.
  • To identify potential inflammatory biomarker profiles associated with obesity in women.

Main Methods:

  • Study included 26 females with obesity and 5 lean controls across two locations (Brooklyn, NY, and Huntington, WV).
  • Measurements included cytokine levels (IL-6, TNFα), adiponectin, Ox-HDL, CECs, and EPCs.

Main Results:

  • Females with obesity exhibited elevated leptin, IL-6, and Ox-HDL levels.
  • Obese females showed increased CEC levels and decreased EPC and adiponectin levels (P < 0.01).
  • Ox-HDL levels were higher in women from Brooklyn compared to Huntington (P < 0.01), potentially linked to TNFα or adiponectin variations. Seventy-five percent of Ox-HDL variance was predictable (P < 0.01).

Conclusions:

  • This study identifies a unique inflammatory biomarker profile in females with obesity.
  • Findings highlight the complex relationship between obesity, inflammation, and endothelial function markers.
Abstract

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