Related Experiment Video

Updated: Jan 31, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

12.0K

Apixaban-induced liver injury

Salvador Machlab1, Mireia Miquel2, Mercedes Vergara2

  • 1Servicio de Aparato Digestivo, Corporació Sanitària Universitària Parc Taulí. Universitat Autònoma de Barcelona, España.

Revista Espanola De Enfermedades Digestivas
|December 21, 2018
PubMed

Insights

New oral anticoagulants like apixaban can cause drug-induced liver injury. This case study highlights a probable link between apixaban and toxic hepatitis, emphasizing the need for vigilance.

Area of Science:

  • Hepatology
  • Pharmacovigilance
  • Internal Medicine

Background:

  • New oral anticoagulants (NOACs), including apixaban, are increasingly prescribed for anticoagulation.
  • While generally considered safe, potential adverse drug reactions require ongoing monitoring.
  • Drug-induced liver injury (DILI) is a significant concern with various medications.

Observation:

  • An 85-year-old patient developed mixed-profile toxic hepatitis.
  • Apixaban was identified as the likely causative agent based on clinical presentation and causality assessment (CIOMS/RUCAM score of 7).
  • Liver biopsy excluded autoimmune hepatitis, and other etiological factors were ruled out.

Findings:

  • The patient's liver injury significantly improved after discontinuing apixaban.
  • Despite a previous meta-analysis suggesting no increased risk of hepatotoxicity with apixaban, over 120 potential cases are reported in EudraVigilance.
  • This case suggests a probable causal relationship between apixaban and liver injury.

Implications:

  • Apixaban should be considered a potential cause of drug-induced liver injury.
  • Clinicians should maintain a high index of suspicion for hepatotoxicity in patients taking apixaban.
  • Further pharmacovigilance studies are warranted to fully elucidate the risk of apixaban-associated liver injury.

More Related Videos

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

5.3K
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury07:27

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

12.4K

Related Concept Videos

Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
4.4K
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.7K
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.1K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.0K
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.4K